Preheat the oven to three hundred and fifty degrees.
In a large bowl, sift together three cups of Bisquick, one-half teaspoon of salt, and one-half teaspoon of baking soda.
In a separate bowl, cream together one-half cup of butter, one-half cup of peanut butter, one cup of brown sugar, and one-quarter cup of white sugar.
With a mixer, add in two eggs, and two teaspoons of vanilla and mix until well combined, scraping the sides of the bowl.
Mix the butter and sugar mixture with the dry ingredients and continue mixing for approximately two minutes.
Fold in two cups of chocolate chips, one cup of peanut butter chips, and one cup of broken pretzels. Chill in the refrigerator for one to two hours.
Place the dough by heaping tablespoons onto a parchment-lined baking sheet and sprinkle each one with sea salt. These cookies will spread out on the pan, so be sure to space them apart. Bake for ten to twelve minutes.
Let cool on the baking sheet before transferring.